Explore the role of preventive washing in reducing ICU-acquired infections and antimicrobial resistance.
Can Preventive Washing Reduce ICU Infections?
Healthcare-associated infections (HCAIs) remain one of the biggest challenges in modern healthcare — affecting up to 37%1 of ICU patients and costing the NHS £2.7 billion each year2.
According to the World Health Organization (WHO), up to 70% of infections can be prevented through effective infection prevention and control3. Preventive washing is emerging as one of the simplest, evidence-based steps to help protect patients, reduce antibiotic use, and strengthen infection prevention across hospitals.
To explore this topic further, experts Dr Philipp Walloch and Dr Roger Henderson share their insights in a three-part podcast series, discussing practical, evidence-based measures that make a difference.
Why Infection Prevention in ICU Matters
Critically ill patients are especially vulnerable to infection due to weakened immune systems and invasive procedures4. Up to 37% of ICU patients develop an HCAI1 — increasing the risk of complications, longer stays, and mortality5.
Key Facts:
- HCAIs affect 7.6% of patients in hospitals2
- Cost the NHS £2.7 billion each year2
- Cause 834,000 infections and 28,500 deaths annually2
- Bloodstream infection prevalence in ICU: 34%4
- WHO: IPC measures reduce HCAIs and AMR by 35–70%3
The Power of Preventive Washing
A simple, evidence-based step toward safer care. For ICU patients, preventive washing with antiseptic products may help lower the risk of bloodstream infections6 and multidrug-resistant organisms (MDROs)7.
Two key approaches:
- Targeted decontamination – for patients testing positive for Staphylococcus aureus
- Universal decontamination – for all ICU admissions
Research shows universal decontamination can prevent up to 45% of MRSA infections8, improving outcomes hospital-wide9.
About the Podcast Series
A three-part conversation tackling one critical question: can preventive washing reduce ICU infections? In this engaging series, Dr Philipp Walloch and Dr Roger Henderson discuss the global challenge of antimicrobial resistance (AMR), the role of infection prevention, and the evidence supporting antiseptic bathing as a simple, effective strategy for ICU teams.
Each episode explores a vital theme:
- The Connection Between AMR and HCAIs – how resistance and infections go hand in hand.
- Prevention Over Treatment – why every infection prevented avoids another antibiotic course.
- The EFFECT Study – large-scale evidence showing antiseptic bathing reduces bloodstream infections by 17%.
Octenidine: The Proven Alternative
Octenidine-based antimicrobial wash mitts have been shown to:
- Reduce ICU-acquired bloodstream infections and MRSA6
- Deliver a 17% reduction in bacteraemia compared to placebo10
- Lower antibiotic prescriptions and unwarranted infections11
- Improve patient and staff satisfaction through waterless convenience12
Octenidine benefits:
- Broad-spectrum antimicrobial action13
- No known resistance10
- Excellent skin compatibility14
- Lasting protection for up to 48 hours15
The octenisan® Range
Effective, patient cleansing for infection prevention. The octenisan® range offers octenidine-based products designed for safe, convenient, and clinically proven decontamination in ICU settings.
- Haque M, Sartelli M, McKimm J, Abu Bakar M. Health care-associated infections - an overview. Infect Drug Resist. 2018;11:2321-2333
- UK Health Security Agency, 2025, Point Prevalence Survey on healthcare-associated infections (HCAIs)
- World Health Organization – Key Facts and Figures – World Hand Hygiene Day https://www.who.int/campaigns/world-hand-hygiene-day/key-facts-and-figures
Accessed 14th October 2025
- Odoom A, Donkor ES. Prevalence of Healthcare-Acquired Infections Among Adults in Intensive Care Units: A Systematic Review and Meta-Analysis. Health Sci Rep. 2025;8(7):e70939
- Nuvials X, Palomar M, Alvarez-Lerma F, et al. Health-care associated infections. Patient characteristics and influence on the clinical outcome of patients admitted to icu. envin-helics registry data. Intensive Care Med Exp. 2015;3(Suppl 1):A82.
- Gastmeier P, Kämpf KP, Behnke M, Geffers C, Schwab F. An observational study of theuniversal use of octenidine to decrease nosocomial bloodstream infections and MDR organisms. J Antimicrob Chemother. 2016;71(9):2569-2576.
- Spencer C, Orr D, Hallam S, Tillmanns E. Daily bathing with octenidine on an intensive care unit is associated with a lower carriage rate of meticillin-resistant Staphylococcus aureus. J Hosp Infect. 2013;83(2):156-159.
- Gidengil CA, Gay C, Huang SS, Platt R, Yokoe D, Lee GM. Cost-effectiveness of strategies to prevent methicillin-resistant Staphylococcus aureus transmission and infection in an intensive care unit. Infect Control Hosp Epidemiol. 2015;36(1):17-27
- Bradley CW, Wilkinson MA, Garvey MI. The Effect of Universal Decolonization With Screening in Critical Care to Reduce MRSA Across an Entire Hospital. Infect Control Hosp Epidemiol. 2017;38(4):430-435.
- Schaumburg T, Köhler N, Breitenstein Y, Kolbe-Busch S, Hasenclever D, Chaberny IF. Publisher Correction: EFFECT of daily antiseptic bathing with octenidine on ICU-acquired bacteremia and ICU-acquired multidrug-resistant organisms: a multicenter, cluster-randomized, double- blind, placebo-controlled, cross-over study. Intensive Care Med. 2025;51(4):833.
- Dhoonmoon L, Dyer M. Improving leg ulcer care in the community. J Comm Nurs, 2020, 34(6): 40–4
- Savage A, Crisford R, Decontamination strategies in ICU, Clinical Services Journal, December 2021.
- Al-Doori Z, Goroncy-Bermes P, Gemmell CG, Morrison D. Low-level exposure of MRSA to octenidine dihydrochloride does not select for resistance. J Antimicrob Chemother. 2007;59(6):1280–1281.
- Vanscheidt W, Harding K,Téot L, Siebert J. Effectiveness and tissue compatibility of a 12-week treatment of chronic venous leg ulcers with an octenidine based antiseptic—a randomized, double-blind controlled study. Int Wound J. 2012;9(3):316–323.
- Malanovic N, Ön A, Pabst G, Zellner A, Lohner K. Octenidine: Novel insights into the detailed killing mechanism of Gram-negative bacteria at a cellular and molecular level. Int J Antimicrob Agents. 2020;56(5):106146.